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KMID : 0613820100200050768
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Journal of Life Science
2010 Volume.20 No. 5 p.768 ~ p.774
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Nitrite Scavenging and Alcohol Metabolizing Activities of Hot Water Extract from Makgeoly and Its Angiotensin Converting Enzyme Inhibitory Effect
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Cho Eun-Kyung
Choi Young-Ju
Kim Hee-Yeon
Byeon Hyeon-Ji
Kim Soo-Won
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Abstract
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In this study, we investigated the antioxidant activities, alcohol metabolizing activities, nitrite scavenging ability, angiotensin converting enzyme (ACE), and elastase inhibitory effects of hot water extract from Makgeoly (HWM). Antioxidant activities were measured by using 2,2 diphenyl 1 picryl hydrazyl (DPPH) free radical scavenging activity and SOD (superoxide dismutase) like activity. The DPPH radical scavenging activity and SOD like activity of HWM were remarkably increased in a dose dependent manner and were 48.0% and 98.7% at 10 ㎎/㎖, respectively. To determine the influence of HWM on alcohol metabolizing activity, the generating activities of reduced nicotinamide adenine dinucleotide (NADH) by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were measured. The facilitating rates of ADH and ALDH activity by HWM were remarkably increased in a dose dependent manner and were 70.2% and 64.1% at 10 ㎎/㎖, respectively. The inhibitory activity against angiotensin converting enzyme (ACE) of HWM was increased in a dose dependent manner and was 74.2% at 10 ㎎/㎖. The nitrite scavenging ability of HWM showed the most remarkable effect at pH 1.2 and 2 ㎎/㎖. These results indicated that HWM may have valuable biological properties owing to their antioxidant activities, ADH and ALDH activity, nitrite scavenging ability, and ACE inhibitory activity.
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KEYWORD
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Makgeoly, antioxidant activities, alcohol metabolizing activities, nitrite scavening activity, angiotensin converting enzyme
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